Endocrine Abstracts

Ectopic lipid deposition in liver and skeletal muscle plays a major role in the pathogenesis of insulin resistance and type 2 diabetes (T2D). Furthermore, nonalcoholic fatty liver disease (NAFLD) is a major predisposing factor for nonalcoholic steatohepatitis (NASH) and hepatocellular cancer and is an independent risk factor of cardiovascular disease. Understanding the cellular and molecular mechanisms by which ectopic lipid promotes insulin resistance in liver and identifying...